The European Conference on Controversies in Huntington's Disease

The conference aims to increase the awareness and interest around main aspects and address controversial questions about Huntington’s Disease, a genetic disabling disorder. One of the largest databases in the world is dedicated to the disease, so the knowledge about clinical phenotypes is going into progressive increase, thanks to a huge number of clinicians and researchers around the world. Nowadays, novel disease-modifying treatments are under human experimentation, and they could represent the possible starting of a new era in HD management.

There are many issues that need to be resolved to improve the outcome of the disease; the clinical onset and the possible interventions in the preclinical stage of the disease, the clinical symptoms of preclinical stage, the real efficacy of drugs as a result of present and past trials, the rehabilitative approach, the clinical expression and treatment of pain.

Talks will be dedicated to controversial issues as regards to the pre-symptomatic phase, reliable biomarkers and the utility or not of predictive test in view of the new pharmacologic opportunities (Bernhard Landwehrmeyer, Caterina Mariotti), pre-symptomatic features of HD (Andrea Horta Barba, Marianna Delussi), results of main pharmacological trials (Giuseppe De Michele, Elena Salvatore), new strategies in rehabilitative approach and neuromodulation (Angela Nuzzi), pain (Marina de Tommaso, Wilco Achterberg, Lydia Giménez Lyort)