54th LISBON International Conference on Genetics, Cellular and Molecular Biology (LGCMB-26)

Topics

All Abstracts, Reviews, short articles, Full articles, Posters are welcomed related with any of the following research fields:

1. Molecular Biology

Molecular biology focuses on the chemical substances and processes involved in biological activity at the molecular level.

The Central Dogma

• DNA Structure & Topology: Double helix, supercoiling, and chromatin packaging.

• DNA Replication: Semiconservative models, replication forks, and telomere maintenance.

• Transcription: RNA polymerase, promoters, enhancers, and the formation of pre-mRNA.

• RNA Processing: Splicing (introns/exons), 5' capping, and polyadenylation.

• Translation: Ribosome structure, tRNA charging, and polypeptide synthesis.

Gene Regulation & Epigenetics

• Prokaryotic Regulation: Operons (e.g., lac and trp operons).

• Eukaryotic Regulation: Transcription factors and distal regulatory elements.

• Epigenetics: DNA methylation, histone acetylation, and chromatin remodeling.

• Non-coding RNA: miRNA, siRNA, and lncRNA in gene silencing.

Molecular Techniques

• Recombinant DNA: Cloning, restriction enzymes, and plasmids.

• Amplification & Sequencing: PCR (Polymerase Chain Reaction), Sanger sequencing, and Next-Generation Sequencing (NGS).

• Genome Editing: CRISPR-Cas9, ZFNs, and TALENs.

2. Genetics

Genetics is the study of genes, genetic variation, and heredity in organisms.

Classical (Mendelian) Genetics

• Laws of Inheritance: Segregation, Independent Assortment, and Dominance.

• Non-Mendelian Inheritance: Incomplete dominance, codominance, and polygenic traits.

• Sex-linked Inheritance: X-linked and Y-linked traits.

Cytogenetics & Chromosomal Theory

• Karyotyping: Chromosome mapping and identification.

• Chromosomal Aberrations: Aneuploidy (e.g., Trisomy 21), deletions, duplications, and translocations.

• Linkage and Mapping: Genetic recombination and crossover frequencies.

Population & Evolutionary Genetics

• Hardy-Weinberg Equilibrium: Calculating allele frequencies in stable populations.

• Forces of Evolution: Mutation, gene flow, genetic drift, and natural selection.

• Quantitative Genetics: Heritability and continuous variation.

Human & Medical Genetics

• Pedigree Analysis: Tracking traits through generations.

• Genetic Disorders: Inborn errors of metabolism, monogenic vs. multifactorial diseases.

• Pharmacogenomics: How genes affect an individual’s response to drugs.

3. Cellular Biology

Cell biology deals with the physical structure, physiological properties, and life cycle of the cell.

Cell Structure & Function

• Organelles: Nucleus, Mitochondria (bioenergetics), Ribosomes, Endoplasmic Reticulum, and Golgi apparatus.

• Membrane Dynamics: Fluid mosaic model, active/passive transport, and endocytosis/exocytosis.

• The Cytoskeleton: Microtubules, microfilaments, and intermediate filaments.

The Cell Cycle & Division

• Mitosis: Stages of somatic cell division ($G_1, S, G_2, M$).

• Meiosis: Gamete formation and genetic shuffling.

• Cell Cycle Control: Checkpoints, cyclins, and CDKs (Cyclin-Dependent Kinases).

Cell Signaling & Communication

• Signal Transduction: Receptors (GPCRs, RTKs), second messengers (cAMP, $Ca^{2+}$), and phosphorylation cascades.

• Apoptosis: Programmed cell death pathways (intrinsic vs. extrinsic).

Metabolic Pathways

• Glycolysis & Respiration: Energy extraction from glucose.

• Photosynthesis: Light-dependent and light-independent reactions (in plant cells).

• Protein Sorting: The secretory pathway and protein targeting (signal peptides).

Interrelated "Bridge" Topics

These fields exist specifically at the intersection of the three main categories:

• Cancer Biology: Genetics (mutations), Molecular Biology (oncogenes), and Cell Biology (uncontrolled division).

• Developmental Biology: How gene expression (Molecular) drives cell differentiation (Cellular) to form an organism.

• Genomics & Proteomics: Large-scale study of the entire genome and the resulting protein set.

• Synthetic Biology: Re-engineering biological systems using molecular tools.