Conference Description:
Peptide drug conjugates (PDCs), a new tool for targeted therapy, consist of a targeting peptide, a linker, and an active drug. Dr Kelly's team synthesized a PDC series of PDCs designed to treat pulmonary fibrosis precisely, combining the kinase inhibitor nintedanib with a mimetic peptide chain targeting the ?V?6 integrin. Their antifibrotic activity is currently being evaluated in a mouse model of pulmonary fibrosis.