Conference Description:

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The objective of this two day "Essentials of USP Microbiology" seminar is to explore USP General and General Information Chapters to learn which are available and to confirm that those that you are using are being used correctly. USP documents that will be reviewed include:

USP Antimicrobial Effectiveness Testing
USP Microbiological Examination of Nonsterile Products: Microbial Enumeration Tests
USP Microbiological Examination of Nonsterile Products: Tests for Specified Microorganisms
USP Sterility Tests
USP Disinfectants and Antiseptics
USP Microbiological Examination of Nonsterile Products
USP Application of Water Activity Determination to Nonsterile Pharmaceutical Products
USP Microbial Characterization, Identification, and Strain Typing
USP Microbiological Control and Monitoring of Aseptic Processing Environments

Various team exercises will be conducted to allow the participants to use these USP documents to solve "real life" problems. Plan to bring a cross-functional group of your personnel to attend this invaluable two day seminar.

Seminar Fee Includes:
Lunch
AM-PM Tea/Coffee
Seminar Material
USB with seminar presentation
Hard copy of presentation
Attendance Certificate
$100 Gift Cert for next seminar

Learning Objectives:

Understanding the various General and General Information USP Chapters that apply to microbiology
The focus of the chapters to include those that primarily involve non-sterile and sterile applications
Chapters that involve the environment
Examining the changes within the various Chapters that have recently occurred and how to interpret them
Review areas that are often overlooked
Study issues that continue to exist between the USP, EP and JP (harmonization)
Examine the new regulatory attitude that is occurring with non-sterile products
What now constitutes a "specified" and "objectionable" microorganism
Explore Form FDA 483s and Warning Letters for microbiological applications



Who Will Benefit:
Manufacturing
Product Development
Project Management
Quality Assurance
Quality Control
Regulatory Affairs
Regulatory Compliance


Topic Background:

Microbiology plays a role throughout the manufacture of pharmaceutical products. Whether the final product is non-sterile or sterile, the bioburden exists within the raw materials, throughout the process and/or within the product's environment (water and HVAC) to the final product. A critical review of the overall microbiological process will determine whether the critical "in-process" points permit the final product to meet its acceptance criteria. In addition, any "objectionable" or "specified" microorganisms that may be encountered during the procurement of raw materials and the processing must be considered.
Whether you are testing a starting material (component), an in-process sample, the Active Pharmaceutical Ingredient (API), final product (whether non-sterile or sterile), the environment to include controlled and classified areas or the HVAC, you should be aware of the critical role the microorganisms play throughout. You should be aware of the various microbiological related documents, e.g., raw material sampling criteria, in-process, API, final product, environmental and utilities, (many of which have USP microbiological documents as the "bedrock" for building these documents, to determine whether the SOPs, validations as well as government and other regulatory body document requirements are being maintained to assure the control required to permit the final product to enter the marketplace as safe.


AGENDA

Day 01(8:30 AM - 4:30 PM)

08.00 AM - 09.00 AM: Registration
09.00 AM: Session Start
Overview of the General and General Information USP Chapters that apply to microbiology
Focus upon those Chapters that primarily involves both non-sterile and sterile applications
Learn how Chapters that involve the environment impact all other USP Chapters
Defining the differences between a “Controlled” and “Classified” environment and how they impact the USP Chapters
Review recently changed USP Chapters to include harmonization and how to interpret them
Team exercises to include commonalities between the various USP documents

Day 02(8:30 AM - 4:30 PM)

Review of areas of USP microbiology that are often overlooked
Study issues that continue to exist between the USP, EP, and JP
Examination of the new regulatory attitude that is occurring with non-sterile products
What now constitutes a “specified” microorganism
Team exercises
Case Studies and recent Warning Letters

SPEAKER

Barry A. Friedman

Barry A. Friedman, Ph.D
Consultant in Biotechnology, Regulatory Compliance and Aseptic Processing Arena
Barry A. Friedman, PhD, is a Consultant in the Biotechnology, Regulatory Compliance and Aseptic Processing Arena. Dr. Friedman possesses over 30 years of industrial managerial experience in various aspects of biopharmaceuticals and medical devices to include regulatory compliance, expert witness testimony, GLP/GMP, quality control, auditing, sterility assurance, microbiological/analytical validations and fermentation technology.
Prior to becoming an independent consultant, Dr. Friedman was associated with Cambrex Bio Sciences, a contract manufacturer of GMP bulk biopharmaceuticals located in Baltimore, Maryland. As the Director of Quality Control, he managed a multi-shift Department of thirty one individuals involved in client management, the receipt and testing of raw materials, environmental monitoring and microbiology, analytical chemistry and QC compliance for the production of Phase 1, 2, 3 and commercial products manufactured from bacteria, yeast and mammalian cells. In this capacity, Dr Friedman enjoyed many client and regulatory interactions, both domestic and international.
Prior to 2000, Dr. Friedman was the Laboratory Director for Chesapeake Biological Laboratories, a contract Aseptic Fill n’ Finish manufacturer located in Baltimore, Maryland. In addition to the professional history listed above, other associations have included W.R. Grace, Sigma Chemical Co., Sherwood Medical, Becton Dickinson, American Cyanamid and Union Carbide.
Dr. Friedman received his B.S. degree in Microbiology from Ohio State University, his M.S. from Michigan State University in Microbial Genetics, and his PhD from Ohio State University in Microbiology.

Please contact the event manager Marilyn ([email protected] ) below for:

- Multiple participant discounts
- Price quotations or visa invitation letters
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